abstract：:The nature of the primary biochemical defect in the human radiosensitive and cancer-prone syndrome, ataxia telangiectasia (AT), has remained obscure despite many efforts to elucidate it. In this study, AT complementation group D cells and a nearly isogenic corrected AT-hamster hybrid derivative have been analyzed for ...

journal_title：Radiation research

authors： Kysela BP,Lohrer H,Arrand JE

更新日期：1995-12-01 00:00:00

abstract：:The objective of this study was to determine whether a deficiency for either one of two repair processes influences the phenomenon of enhancement of radiation-induced cell killing by carboplatin which has been reported previously in one cell line (V79) and which is presumably a result of an interaction between these t...

journal_title：Radiation research

authors： Yang L,Douple EB,O'Hara JA,Crabtree RA,Eastman A

更新日期：1995-11-01 00:00:00

abstract：:The first hundred years of radiation studies have greatly clarified the chemical processes that are induced by radiation. While the fundamental ionization processes are similar in all systems, properties of the medium such as phase, polarity and composition can greatly affect the chemistry. In all systems, one needs t...

journal_title：Radiation research

authors： Jonah CD

更新日期：1995-11-01 00:00:00

abstract：:The present study was undertaken to assess the protective effect of dimethyl sulfoxide (DMSO) against the induction and rejoining of DNA double-strand breaks (DSBs) and inactivation of V79-4 Chinese hamster cells by both high- and low-linear energy transfer (LET) radiations. The cells were exposed under aerobic condit...

journal_title：Radiation research

authors： deLara CM,Jenner TJ,Townsend KM,Marsden SJ,O'Neill P

更新日期：1995-10-01 00:00:00

abstract：:Metallothionein (MT), the synthesis of which can be induced by metalloelement administration, is a known radical scavenger. This study investigated the possible protective effect of MT against acute radiation injury. Manganese chloride (10 mg of manganese/kg) was administered intraperitoneally to male C3H/He mice 24 h...

journal_title：Radiation research

authors： Murata R,Nishimura Y,Hiraoka M,Abe M,Satoh M

更新日期：1995-09-01 00:00:00

abstract：:It has been shown that several X-ray-sensitive Chinese hamster cell mutants defective in repair of DNA double-strand breaks (DSBs) are also impaired in the process of V(D)J recombination. The hamster mutants with this phenotype represent three distinct complementation groups, represented by the xrs series, XR-1 and V-...

journal_title：Radiation research

authors： Zdzienicka MZ,Jongmans W,Oshimura M,Priestley A,Whitmore GF,Jeggo PA

更新日期：1995-09-01 00:00:00

abstract：:A method was used to detect chromosome inversions as apparent or false sister chromatid exchanges (SCEs) in the first mitosis after gamma irradiation of human G0 cells. Dose-response relationships for small inversions have not been measured and reported previously, but it has been assumed that these are induced with a...

journal_title：Radiation research

authors： Mühlmann-Díaz MC,Bedford JS

更新日期：1995-08-01 00:00:00

abstract：:The effect of acute exposure to ultrawideband (UWB) electromagnetic radiation on the Primate Equilibrium Platform (PEP) task, where the monkey's task is to manipulate a joystick control to compensate for the random perturbations in the pitch plane that are generated by a computer at unpredictable intervals, was examin...

journal_title：Radiation research

authors： Sherry CJ,Blick DW,Walters TJ,Brown GC,Murphy MR

更新日期：1995-07-01 00:00:00

abstract：:The effect of both hyperthermia and verapamil on cytotoxicity and transport of melphalan was studied in a pleiotropic drug-resistant Chinese hamster ovary cell line (CHRC5) and in the drug-sensitive parent line (AuxB1). The CHRC5 cell line was selected for resistance to colchicine but is also cross-resistant to other ...

journal_title：Radiation research

authors： Averill-Bates DA,Courtemanche B

更新日期：1995-07-01 00:00:00

abstract：:Current lung cancer risk estimates after exposure to low-linear energy transfer radiation such as X rays are based on studies of people exposed to such radiation at high dose rates, for example the atomic bomb survivors. Radiobiology and animal experiments suggest that risks from exposure at low to moderate dose rates...

journal_title：Radiation research

authors： Howe GR

更新日期：1995-06-01 00:00:00

abstract：:The effectiveness of 5-fluorouracil (5-FU), FT-207 and FT-207 + uracil in combination with two repetitions of 43 degrees C hyperthermia in the treatment of the Meth-A-Fibrosarcoma and Sarcoma-180 was examined in vivo in BALB/c mice. The antitumor effect was evaluated in terms of inhibition of tumor growth by measuring...

journal_title：Radiation research

authors： Harada S,Ping L,Obara T,Oikawa H,Miyata M,Matsuo M,Takahashi T,Yanagisawa T

更新日期：1995-05-01 00:00:00

abstract：:Results from several laboratories, including ours, have suggested that measurements of radiation-induced DNA strand breaks and DNA-protein crosslinks (DPCs) may be used to estimate the hypoxic fraction or fractional hypoxic volume of tumors and normal tissues. This suggestion has been predicted on both published and u...

journal_title：Radiation research

authors： Zhang H,Koch CJ,Wallen CA,Wheeler KT

更新日期：1995-05-01 00:00:00

abstract：:Domestic radon risk estimates are typically based either on data for uranium miners or on data derived from A-bomb survivors; comparison of domestic radon risk estimates derived from these two disparate sources represents an important test of their reliability. There is currently a significant discrepancy of about a f...

journal_title：Radiation research

authors： Brenner DJ,Miller RC,Huang Y,Hall EJ

更新日期：1995-04-01 00:00:00

abstract：:The LD50 of 46 salts of metals and rare earths (lanthanoids) was determined in mice. Half the LD50 of the compounds was then combined with lethal radiation (10.5 Gy) and the modification of survival time was scored. Only the metals beryllium and indium and the rare earths cerium, lanthanum and scandium displayed activ...

journal_title：Radiation research

authors： Floersheim GL

更新日期：1995-03-01 00:00:00

abstract：:Radiation-induced apoptosis in lymphocyte-derived cell lines is characterized by endonucleolytic cleavage of cellular DNA within hours after radiation exposure. We have studied this phenomenon qualitatively (DNA gel electrophoresis) and quantitatively (diphenylamine reagent assay) in murine EL4 T-lymphoma cells expose...

journal_title：Radiation research

authors： Palayoor ST,Macklis RM,Bump EA,Coleman CN

更新日期：1995-03-01 00:00:00

abstract：:Experimentally derived optical constants and X-ray attenuation cross sections were used to construct the complete dipole oscillator strength distribution for solid, dry DNA. Monte Carlo simulations of the energy loss by electrons of initial energy 5 keV to 1 MeV in DNA were performed using cumulative inelastic cross s...

journal_title：Radiation research

authors： LaVerne JA,Pimblott SM

更新日期：1995-02-01 00:00:00

abstract：:Evidence is presented for the formation of products in irradiated dinucleoside monophosphates in which both bases are damaged. The dinucleoside monophosphates d(GpT), d(GpC), d(TpG) and d(CpG) were X-irradiated in oxygenated aqueous solution. Product identification was by NMR spectroscopy. In products containing doubl...

journal_title：Radiation research

authors： Box HC,Freund HG,Budzinski EE,Wallace JC,Maccubbin AE

更新日期：1995-01-01 00:00:00

abstract：:X rays have been shown to induce two forms of potentially lethal damage (PLD), "fast-repairing" PLD and "slowly repairing" PLD, whose repair is completed in 1 h and 4-6 h, respectively. In this study three modes of treatment with hypertonic solutions containing different NaCl concentrations for different durations (0....

journal_title：Radiation research

authors： Ikebuchi M,Kimura H,Hill CK,Aoyama T

更新日期：1995-01-01 00:00:00

abstract：:Statistical analysis of Monte Carlo simulations of positive ion track structure is presented for 1 MeV protons passing outside an absorbing region of interest. Energy deposition and production of ionization within the region occur only by delta-ray transport from the ion's path. Depositions in spherical absorber regio...

journal_title：Radiation research

authors： Wilson WE

更新日期：1994-12-01 00:00:00

abstract：:Solid thymidylyl-(3'-->5')-thymidine (dTpdT) was irradiated in a vacuum with monochromatic photons from 150 to 300 nm; the photoproducts were analyzed quantitatively by high-performance liquid chromatography. The results of the experiment were as follows: (1) above 210 nm the major photoproducts were three dithymine p...

journal_title：Radiation research

authors： Saitou M,Hieda K

更新日期：1994-11-01 00:00:00

abstract：:Previous work by our group and others has shown the modulation of human immunodeficiency virus (HIV) promoter or long terminal repeat (LTR) after exposure to neutrons and ultraviolet radiations. Using HeLa cells stably transfected with a construct containing the chloramphenicol acetyl transferase (CAT) gene, the trans...

journal_title：Radiation research

authors： Libertin CR,Panozzo J,Groh KR,Chang-Liu CM,Schreck S,Woloschak GE

更新日期：1994-10-01 00:00:00

abstract：:Cells from patients with ataxia telangiectasia (AT) are abnormal in their response to irradiation as judged by clonogenic survival and accumulation in G2 phase. The relationship of the results of these two assays, however, is still a matter of controversy. Flow cytometry was used to measure the distribution of cells i...

journal_title：Radiation research

authors： Hong JH,Gatti RA,Huo YK,Chiang CS,McBride WH

更新日期：1994-10-01 00:00:00

abstract：:Total-body irradiation (TBI) induces an increase in levels of granulocytes and cortisol in blood. To explore the underlying mechanisms, we studied 26 patients who had TBI prior to bone marrow transplantation. Our findings suggest that only a high dose of TBI (10 Gy) was capable of activating the hypothalamo-pituitary ...

journal_title：Radiation research

authors： Girinsky TA,Pallardy M,Comoy E,Benassi T,Roger R,Ganem G,Cosset JM,Socié G,Magdelenat H

更新日期：1994-09-01 00:00:00

abstract：:Acute thermotolerance was induced in Chinese hamster ovary cells by heating at 43 degrees C for 45 min followed by incubation at 37 degrees C for up to 85 h. The degree of thermotolerance induced was quantified by a second heat exposure at 43 degrees C. To study the interaction of thermotolerance and thermosensitizati...

journal_title：Radiation research

authors： Jung H

更新日期：1994-09-01 00:00:00

abstract：:A subline of a rat mammary carcinoma (MATB 13762), selected for resistance to melphalan, is cross-resistant to other alkylating drugs, to unrelated drugs and to ionizing radiation. The difference in radioresponse between the sensitive wild-type cell line and the melphalan- and radiation-resistant line (MLNr) is relate...

journal_title：Radiation research

authors： Lehnert S,Vestergaard J,Batist G,Aloui-Jamali MA

更新日期：1994-08-01 00:00:00

abstract：:Plateau-phase A549 cells exhibit a high capacity for repair of potentially lethal radiation damage (PLD). Previously it was found that PLD repair could be partially inhibited by increasing the extracellular pH (pHe) of the spent medium from its normal value of 6.7-6.8 to 7.6 during postirradiation holding. The present...

journal_title：Radiation research

authors： Jayanth VR,Bayne MT,Varnes ME

更新日期：1994-08-01 00:00:00

abstract：:A rare T-cell subpopulation, CD4-8- alpha beta T cells, may be differentiated through a pathway (or pathways) different from the pathway(s) of conventional CD4+ or CD8+ T cells. In the present study, the frequencies of CD4-8-T cells in peripheral-blood alpha beta T cells in 409 atomic bomb survivors (160 estimated to ...

journal_title：Radiation research

authors： Kusunoki Y,Kyoizumi S,Hirai Y,Fujita S,Akiyama M

更新日期：1994-07-01 00:00:00

abstract：:Tissue-incorporated radionuclides impart radiation energy over extended periods of time depending on their effective half-lives. The capacity of vitamin A dissolved in soybean oil to protect against the biological effects caused by internal radionuclides is investigated. The radiochemicals examined are DNA-binding 125...

journal_title：Radiation research

authors： Harapanhalli RS,Narra VR,Yaghmai V,Azure MT,Goddu SM,Howell RW,Rao DV

更新日期：1994-07-01 00:00:00

abstract：:The relationships between DNA damage and the survival of murine bone marrow cells irradiated in situ were examined. Cell survival was assayed by the ability of bone marrow cells from irradiated mice to form colonies in vitro (CFU-C). DNA double-strand breaks (DSBs) were measured by neutral (nondenaturing) filter eluti...

journal_title：Radiation research

authors： Petrovecki M,Prager A,Terry NH,Murray D

更新日期：1994-06-01 00:00:00

abstract：:Evaluation of the probability of biological phenomena per cell by colony formation, requires knowledge not only of the number of cells at risk but also of their microdistribution. In the present study, the influence of cellular multiplicity (number of cells per potential colony-forming unit) on the determination of ra...

journal_title：Radiation research

authors： Gerweck LE,Dullea R,Zaidi ST,Budach W,Hartford A

更新日期：1994-06-01 00:00:00

abstract：:The correlation between the protein content of nuclei and heat-induced cell killing was determined for HeLa cells with various levels of thermotolerance. Thermotolerance was induced by heating cells at 45 degrees C for 15 or 30 min and then incubating them at 37 degrees C for 5 or 24 h. This procedure resulted in four...

journal_title：Radiation research

authors： Roti Roti JL,Turkel N

更新日期：1994-05-01 00:00:00

abstract：:The radiation dose received by crew members in interplanetary space is influenced by the stage of the solar cycle. Using the recently developed models of the galactic cosmic radiation (GCR) environment and the energy-dependent radiation transport code, we have calculated the dose at 0 and 5 cm water depth; using a com...

journal_title：Radiation research

authors： Badhwar GD,Cucinotta FA,O'Neill PM

更新日期：1994-05-01 00:00:00

abstract：:Many studies have demonstrated the effect of oncogene transfection on the radiation sensitivity of primary rat embryo fibroblasts. Our results indicate that transformation by H-ras plus v-myc oncogenes confers radiation resistance to a much greater extent than transformation by either gene alone. We have further shown...

journal_title：Radiation research

authors： Bernhard EJ,McKenna WG,Muschel RJ

更新日期：1994-04-01 00:00:00

abstract：:We have monitored the end points of cellular survival, micronucleus formation and neoplastic transformation frequency to assess adaptation to ionizing radiation in the C3H 10T1/2 mouse embryo cell system. Plateau-phase cells were pre-exposed to an adapting dose of 0.1 to 1.5 Gy low-dose-rate gamma radiation 3.5 h prio...

journal_title：Radiation research

authors： Azzam EI,Raaphorst GP,Mitchel RE

更新日期：1994-04-01 00:00:00

abstract：:We have been investigating radiation-induced neoplastic transformants of C3H 10T1/2 mouse fibroblasts for evidence of heritable changes. C3H 10T1/2 cells were treated with 8 Gy X rays. After approximately 8 weeks of culture, type II/III foci were isolated from the monolayer using cloning rings. Cell lines developed fr...

journal_title：Radiation research

authors： Crompton NE,Sigg M,Jaussi R

更新日期：1994-04-01 00:00:00

abstract：:Incorporation of bromodeoxyuridine (BrdU) into DNA in both Chinese hamster ovary (CHO) cells and human melanoma (U1) cells reduced the rate of DNA migration in transverse alternating-field electrophoresis (TAFE) agarose gel optimized for separating molecules larger than 2 Mb. This "BrdU migration effect" was independe...

journal_title：Radiation research

authors： Latz DL,Trinh MM,Thompson LL,Gardiner K,Zhu Y,Bodell WJ,Dewey WC

更新日期：1994-04-01 00:00:00

abstract：:The effect of X irradiation on the respiration of rat thymocytes was studied. An increase in the rate of O2 uptake was observed 1 h after cells were irradiated with doses of 6-10 Gy. The radiation-induced increase in respiration could be blocked by oligomycin, an inhibitor of mitochondrial ATP synthase, suggesting con...

journal_title：Radiation research

authors： Gudz TI,Pandelova IG,Novgorodov SA

更新日期：1994-04-01 00:00:00

abstract：:A total of 155 primary bone sarcomas were found in 131 of the 246 beagles injected with 226Ra and 5 primary bone sarcomas were found in 4 of the 158 unexposed controls. Of these 155 bone sarcomas, 146 (94%) were osteosarcomas and 9 were non-osteosarcomas. An additional 31 primary bone sarcomas (28 osteosarcomas) devel...

journal_title：Radiation research

authors： White RG,Raabe OG,Culbertson MR,Parks NJ,Samuels SJ,Rosenblatt LS

更新日期：1994-03-01 00:00:00

abstract：:Fluorescence in situ hybridization procedures were used to examine the influence of chromosome locus on the frequency and type of chromosome aberrations induced by 60Co gamma rays in the human lymphoblastoid cell line TK6. Aberrations involving the X chromosome were compared to those involving the similarly sized auto...

journal_title：Radiation research

authors： Jordan R,Schwartz JL

更新日期：1994-03-01 00:00:00

abstract：:The potential carcinogenic effects of internally deposited alpha-particle-emitting nuclides, notably plutonium, in the liver in humans are unknown but are of concern in relation to exposures from the nuclear industry. However, patients injected with the radiographic contrast medium Thorotrast are chronically exposed t...

journal_title：Radiation research

authors： Andersson M,Vyberg M,Visfeldt J,Carstensen B,Storm HH

更新日期：1994-02-01 00:00:00